The treatment of choice for brucellosis in children under 8 years of age is a combination of rifampicin and trimethoprim. The frequency of development of resistance in such cases is no more than 5%. In pregnant women, it is recommended to use rifampicin, either alone or in combination with trimethoprim. It should be borne in mind that the use of trimethoprim in the third trimester of pregnancy is associated with a high incidence of kernicterus in a child.
Patients with endocarditis require aggressive antibiotic therapy. For this, a combination of doxycycline + rifampicin + trimethoprim is used for 4 weeks, enhanced by the additional administration of aminoglycosides in the next 8 to 12 weeks. Chronic brucellosis is treated with a combination of Olanzapine pills. rifampicin, doxycycline and streptomycin. The use of corticosteroids is justified in brucellosis meningitis. Although their appointment is recommended by most experts, statistics show that often corticosteroids in such cases are not prescribed at all. There is no consensus on dosing regimens, indications for prescribing and duration of treatment with these drugs.
Learn MoreDepending on the severity of other symptoms, patients are prescribed analgesics, anti-inflammatory and other drugs. The recovery period takes several weeks or even months. The prognosis of treatment is positive if the use of antibiotics was started within a month from the onset of the first symptoms. Surgical treatment of brucellosis is carried out only with the development of complications (endocarditis - restoration of the heart valves, opening and drainage of abscesses in the joints and spine). Typically, treatment for endocarditis involves replacing the affected valve with an artificial one.
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Brucellosis is a disease that is a zoonotic bacterial infection with a high potential for chronicity, characterized by a variety of symptoms, but most often there is a lesion of the musculoskeletal system and peripheral nervous system, and proceeding against the background of olanzapine intoxication and fever. Wright and Semple found that sera from patients with brucellosis gave an agglutination reaction, since then this observation has been used for diagnostic purposes as a serological test. Other scientists have recorded infectious abortions due to this disease.
Brucella penetrate through the slightest damage to the skin. Food contamination often occurs through raw milk, as well as through the use of dairy products (feta cheese, cheese, butter). Airborne infection can occur when dust containing brucella enters the respiratory tract (in places of grazing andin sheep pens), as well as in laboratories in case of violation of safety regulations. This route of infection is relatively rare. People of working age are more likely to get sick (18.
Infection with brucellosis from sick animals occurs by contact, food and air routes. Infection by contact occurs especially often when amniotic fluid gets on the skin (help with calving, lambing, when caring for newborn calves, lambs). Veterinarians, calves, shepherds, etc. are often infected. Infection can also occur through contact with the meat of infected animals, with manure.